一、基本情况介绍

胡金星，男，副教授，博士，硕士生导师。

二、教学工作

承担《药物化学》及《药物合成反应》教学工作。

三、科研工作

1、主持或参加科研项目（限5项以内）

[1] 基于C797S共晶蛋白结构的新型蝶啶类EGFR激酶抑制剂的设计、合成及抗肿瘤活性研究, 国家自然科学基金青年科学基金项目, 81903469, 2020-01至2022-12, 21万元, 主持, 结题。

[2] 山东省高等学校“青创团队计划”--小分子靶向药物研发青年创新团队, 2023-01至2025-12, 30万，主持，在研。

[3] 克服C797S耐药的新型EGFR激酶抑制剂的设计、合成以及抗肿瘤活性研究, 潍坊市科技局, 2019-9至2021-9, 2万元, 主持, 结题。

2、代表性论著（限5项以内）

[1]Rongcai Ding1, Xiaoxia Wang1, Jianfang Fu, YaoyaoChang, YingxueLi, YajingLiu, Yue Liu, Jinlong Ma*, Jinxing Hu*, Design, synthesis and antibacterial activity of novel pleuromutilin derivatives with thieno[2,3-d]pyrimidine substitution, Eur. J. Med. Chem, 2022, 237, 114398.

[2] Yingxue Li1, Yaoyao Chang1, Jianfang Fu, Rongcai Ding, Lingyun Zhang, Tian Liang，Yajing Liu, Yue Liu*, Jinxing Hu*. Design, synthesis and biological evaluation of aminopyrimidine derivatives bearing a 4,5,6,7-tetrahydrothieno [3,2-c]pyridine as potent EGFR inhibitors, Eur. J. Med. Chem, 2021, 226, 113845.

[3] Yaoyao Chang1, Jianfang Fu1, Yingxue Li, Rongcai Ding, Yue Liu* and Jinxing Hu*; Pd-Catalyzed Rearrangement Reaction of N-Tosylhydrazones Bearing Allyl Ethers Into Trans-Olefin-Substituted Sulfonylhydrazones, Front. Chem, 2021, 9, 782641

[4] Rongcai Ding, Yingxue Li, Yaoyao Chang, Yue Liu, Jie Yu, Yanna Lv* and Jinxing Hu*; Metal-Free Direct C-H Functionalization of Quinoxalin-2(1H)-Ones to Produce 3-Vinylated Quinoxalin-2(1H)-Ones in the Presence of Alkenes, Front. Chem, 2021, 9, 672051.

[5] Rongcai Ding, Rongmei Lu, Zixuan Fang, Yanjun Liu, Shaoyu Wang, Xiaoxia Liang, Cheng Zhang, Tianyi Huang, and Jinxing Hu*; Synthesis of 4,5-Dihydropyrazoles via Palladium-Catalyzed Cyclization Reactions of β,γ-Unsaturated Hydrazones with Aryl Iodides, Organometallics, 2019, 38: 4561−4564.