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胡金星

发布者:yxy    发布时间:2020-04-28

一、基本情况介绍

胡金星,男,讲师,博士,硕士生导师。

二、教学工作

承担《药物化学》及《药物合成反应》教学工作。

三、科研工作

1、主持或参加科研项目(限5项以内)

[1] 基于C797S共晶蛋白结构的新型蝶啶类EGFR激酶抑制剂的设计、合成及抗肿瘤活性研究, 国家自然科学基金青年科学基金项目, 81903469, 2020-01至2022-12, 21万元, 在研, 主持

[2] 克服C797S耐药的新型EGFR激酶抑制剂的设计、合成以及抗肿瘤活性研究, 潍坊市科技局, 2019-92021-9, 2万元, 在研, 主持

2、代表性论著(限5项以内)

[1] Yue Liu, Cheng Zhang, Xiaoxia Liang, Xianzhong Zeng, Rongmei Lu, Zixuan Fang, Shaoyu Wang, Yanjun Liu, Jinxing Hu*.Synthesis of 2-Imidazolines via Palladium-Catalyzed Cyclization Reaction of 2,3-Allenyl Amines and Aryl Iodides, Synthesis, 2020, 52: 901–908.

[2] Rongcai Ding, Rongmei Lu, Zixuan Fang, Yanjun Liu, Shaoyu Wang, Xiaoxia Liang, Cheng Zhang,Tianyi Huang, and Jinxing Hu*. Synthesis of 4,5-Dihydropyrazoles via Palladium-Catalyzed Cyclization Reactions of β,γ-Unsaturated Hydrazones with Aryl Iodides, Organometallics, 2019, 38(24):4561-4564.

[3] Jinxing Hu, Yufei Han, Jingtao Wang, Yue Liu, Yanfang Zhao, Yajing Liu*, Ping Gong*.Discovery of selective EGFR modulator to inhibit L858R/T790M double mutants bearing a N-9-Diphenyl-9H - purin-2-amine scaffold, Bioorganic & Medicinal Chemistry, 2018, 26(8): 1810-1822.

[4] Jinxing Hu, Zefei Li, Xian Zhang, Yufei Han, Yue Liu, Yanfang Zhao, Yajing Liu,* and Ping Gong*.Palladium-Catalyzed Cyclization Reaction of Oxime Acetates and Aryl Iodides: Syntheses of 2Imidazolines. Organic Letters2018, 20(7): 2116-2119.

[5] Jinxing Hu, Bo Kong, Yue Liu, Boxuan Xu, Yanfang Zhao,* and Ping Gong*.Highly Stereoselective Synthesis of Imidazolidines through the Palladium(0)-Catalyzed Three-Component Reaction of 2,3-Allenylamines, Organic Halides, and Imines. ChemCatChem, 2017, 9: 403-406